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Combination studies with semaglutide consistently outperformed the GLP-1 drug on its own, which is the cleanest available evidence that an amylin analog adds to, rather than duplicates, incretin-based weight loss

doi: 10.1186/s41936-020-00148-0 14

Seek medical help right away if you notice: severe or persistent abdominal pain and/or constipation, repeated vomiting, inability to keep fluids down, or fainting signs of an allergic reaction, such as swelling, hives, or trouble breathing (seek emergency care) any new, concerning, or sudden symptom after starting the medication or increasing the dose that doesnt improve Key Takeaways Semaglutide and tirzepatide are effective and safe weight loss medications that are designed to be paired with a healthy diet and exercise